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An estimated 400 million people worldwide are affected by G6PD deficiency, which is more prevalent on the African continent, in the Middle East, and Southeast Asia [[26], [27], [28], [29]]
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We found that the RIPK1 S32A mutation significantly augmented the inhibitory effect of PD-1 monoclonal antibody on tumor growth and exacerbated tumor cell injury, with this effect being more pronounced following HK2 knockout
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