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AngI serves as a substrate for angiotensin Converting Enzyme (EC 3.4.15.1) which is responsible for hydrolyzing the carboxy terminal dipeptide His-Leu to form AngII
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Instead, they function by inhibiting the activity of peripheral DOPA decarboxylase (DDC), which reduces the conversion of levodopa in peripheral tissues and increases its availability in the central nervous system, while also minimizing side effects such as nausea and vomiting (van Rumund et al., 2021)
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