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In the IFNγ-cuprizone model, which allows for assessment of OPC differentiation and remyelination in an IFNγ-high environment, prolonging the integrated stress response with the compound Sephin1 increased the number of remyelinating oligodendrocytes and remyelinated axons
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By inhibiting NNMT, 5-Amino-1MQ preserves more nicotinamide for NAD+ salvage — preventing the diversion of nicotinamide to methylation and excretion
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