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Neurotrauma 34 , 2753–2759 (2017)

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Moreover, the activation of GPR81 can also mimic a similar potency as the lactate ( iα subunit to inhibit the intracellular adenylate cyclase (AC)-cyclic adenosine monophosphate (cAMP) cascade signal that contributes to the reduction of exocytosis ( iβ subunit to regulate the activity of phospholipase C (PLC) and thus inhibit neuronal excitability ( + ) indrawal or activating the GABA receptor for exocytosis reduction (85) (Figure 2)