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It depends on two primary variables: Volume of distribution (Vd) Clearance (CL) 💡 Formula: t½ = (0.693 × Vd) / CL Vd = how widely the drug is distributed CL = how quickly it's eliminated 🔍 Interpreting the Curve 🧠 KOTC Tip: It takes ~4–5 half-lives to reach steady state or complete elimination

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