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Further study showed that procainamide inhibited the activity of DNMT1 but not DNMT3A/3B ( 57 ) is a novel amino benzoic acid DNMTi screened from 169 procainamide derivants by the Ohio State University, which caused the reversal of promoter hyper methylation of GSTP1 and TRIP10 genes in MCF7 breast cancer cells and induced global hypomethylation and hypomethylated more loci than procainamide and 5-aza-2′-deoxycytidine (Lin et al., 2011b)
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