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Random-effects models, which assume variability in effects from both sampling error and study level differences [36,37], were used to calculate incidence across studies (AEs Meta-analysis) while pooled Cohen’s d’ (a measure of effect size) was calculated from the standardized mean difference of outcome measures using the inverse variance heterogeneity model since it has been shown to resolve issues with underestimation of the statistical error and spuriously overconfident estimates with the random effects model when analyzing continuous outcome measures (Biochemistry Meta-analysis) [38]

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Which could make you question, is B12 the issue, or is it an imbalance in the skin microbiome that’s reacting to high-dose B12