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Of these, 78 were included, whereas 291 were eliminated for the following reasons: 73 were out of scope, 139 were repeats of previously included material, 13 lacked appropriate information, and 66 had irrelevant results

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(2014a, 2014b) provided compelling evidence that morphine may cause dependence/addiction by blocking the entry of L-cysteine into neurons by inhibition of the EAA3/EAAC1 transporter, thereby reducing L-cysteine-dependent cell signaling pathways (Yamaguchi and Hosokawa, 1987