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Furthermore, norepinephrine has the potential to promote the synthesis of pro-inflammatory cytokines by upregulating the activity of Nuclear Factor Kappa B ( NF-κB ) through key inflammation- or proliferation-related pathways such as those of JNKs and p38-MAPKs

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Management of acute ankle sprains initially focuses on reducing inflammation and protecting the joint, utilizing rest, ice, compression, and elevation alongside early functional rehabilitation