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Whether the isolated fragment can recapitulate that presentation is exactly the question, and the structural argument cuts both ways: it explains why a fragment might behave differently from the parent, and it also explains why a fragment might fail to behave like the parent at all

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Moreover, over 40% of people who start taking GLP-1s quit the medicines within 2 years due to high costs and gastrointestinal side effects such as nausea, diarrhea, vomiting, and constipation, according to a study published in JAMA Network Open last year