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Organic anion transporter 3(OAT3) is mainly expressed in the kidney, and the absence of OAT3 alters the normal metabolite transport function in the gut-liver-kidney axis, resulting in the accumulation of endogenous lipid metabolites, such as bile acids and lipids, and G-protein-coupled receptor 35(GPR35), which is a key receptor for lipid metabolism
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245 A GFD sustains a physiological microbiome, increases luminal SCFA, and combined with a high-fiber diet, could enhance enteric IgA levels
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