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Cancer cells have a special metabolic shifting that represents another critical feature of developed resistance, where persistent mTOR inhibition pushes tumor cells to increase their dependance on different metabolic signaling pathways, such as GLUT1 stimulation to increase glucose usage through, aerobic glycolysis, and stimulation of autophagy for prorogation purpose (233)
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doi: 10.1016/j.envint.2013.07.019
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