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9 Relevant genes for SSRI action and antidepressant metabolism Selective serotonin reuptake inhibitors (SSRIs), such as citalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline, were developed as an alternative to tricyclic antidepressants (TCAs), with the aim of maintaining effective treatment for depression while improving safety and tolerability ( CYP2D6 and CYP2C19 genes ( Although selective serotonin reuptake inhibitors (SSRIs) share a common mechanism of action centered on the blockade of serotonin reuptake transporters, they differ considerably in their chemical structures and secondary mechanisms, which contribute to variability in their pharmacodynamic and pharmacokinetic profiles