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There is an interesting parallel here because these three molecules, which were initially thought to be exclusively toxic, may in fact represent key regulators for various biological processes and in particular for signaling purposes, considering their relative stability, their capacity to diffuse across membranes (·NO) and H 2 S are gases and the uncharged H 2 O 2 is channeled via aquaporins) and their propensity to react with thiolates (Bienert et al., 2007)

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Follistatin can bind members of the TGF beta superfamily, including myostatin and activin-related ligands