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Its distribution in northern Africa, southern Asia, the Mediterranean countries, and Middle Eastern regions matches that of high-malaria ( Plasmodium falciparum –caused) prevalence

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Specifically, in the morphine-induced constipation model mice, we demonstrate that morphine inhibits PVN Glu neuronal activity through MOR, thereby reducing DMV Ach neuronal activity, which leads to decreased small intestinal motility and a reduced transit rate, ultimately manifesting in constipation