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However, the remainder of this neuroimaging study section will focus on the application of 1 H-MRS to examine glutamatergic abnormalities in schizophrenia

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These changes not only impair cellular energy production but also exacerbate oxidative stress, further inhibiting glycolytic activity.74,78 Moreover, multiple studies have shown that manipulating Sirt2 in granulosa cells can effectively improve insulin resistance and activate glycolytic pathways, promoting lactate metabolism in granulosa cells.79,80 This is consistent with earlier studies indicating that Sirt2 expression is related to glycolytic activity in cells