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With regard to the live helminths used in the studies, Trichuris suis does not typically infect humans and exists naturally as a porcine parasite (Cutillas et al ., )
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The global knock-out of PGC1α, a key transcriptional regulator of mitochondrial proteins, enhanced the serum BUN and creatinine levels in mice, indicative of the important role of mitochondrial bioenergetics in the maintenance of renal integrity (Mei and Tam, 2011)
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