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These observations are consistent with the previous report that Gsr hypomorphic mice are viable and appear healthy, [7] and the phenotypic data of Gsr homozygous knockout mice on the 129SvEv Brd ;C57BL/6J background characterized by Lexicon Genetics ( In the current study, young Gsr homozygous knockout mice displayed an 80% decrease in GSR activity in the cytosol of the inner ears (Fig 8A), despite the fact that Gsr -/- mice displayed no detectable level of GSR in the inner ear (Fig 3A and 3B)