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that adhere to the bowel mucosa have been implicated in the pathogenesis of joint disease 131,132
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In the acidic environment of endosomes, the lowered pH facilitates the release of Feยณโบ from the Tf-TfR1 complex, allowing TfR1 and apotransferrin (apoTF) to be recycled back to the cell surface (Klausner et al., 1983
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