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Because a good correlation has been established between in vitro metabolism dependent mutagenic response and the outcome of rodent carcinogenicity evaluations, drug candidates intended for non-life-threatening indications are generally discontinued from development, when they exhibit a positive response in the in vitro assays in the presence of S-9/NADPH
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Measurements of BALF total cell count revealed a significant reduction in immunocyte infiltration in ALI mice with BDP-12 injection (Fig
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