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BBB Transport Mechanisms Have Unique Physicochemical Profiles Essential for BBB Permeation To investigate which physicochemical properties are important for BBB permeation per transport mechanism in our datasets, we developed an XGBoost prediction model for each dataset (Figure 2A, the performances of all models are shown in Table S1)

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Inducing the expression of TJ proteins after BBB breakdown could accelerate BBB reestablishment and reduce disease severity, as shown in mice with EAE 140,144