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First described more than 60 years ago, the deleterious effects of excessive histamine ingestion were initially referred to as scombroid fish poisoning or scombrotoxicosis, as they were associated with the consumption of fish in this family, but the condition is now known as histamine intoxication or histamine poisoning

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When KPV is the research tool of choice: Studies focused on the cytokine environment of inflamed bowel — particularly the NF-κB/IL-1β/TNF-α axis — have used KPV as a tool to test the hypothesis that melanocortin receptor activation modulates macrophage polarization and epithelial barrier function