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These different absorption rates could perhaps be attributed to a greater lipophilicity of PHITC ( After the initial conjugation with GSH catalyzed by the enzyme GST, the conjugates are metabolized to a mercapturic acid derivate (N-acetyl-cysteine-ITC [NAC-ITC]), which is excreted in the urine (Figure 2 shows a schematic representation of the factors influencing the amount of GLSs ingested, their absorption, distribution, metabolism, and excretion